Description

(-)-1,4-Di-o-Methyl-L-Threitol CAS NO 50622-10-1 is a high-purity, chiral diol derivative of L-threitol, serving as a critical chiral building block and ligand in asymmetric synthesis. Its value lies in its ability to impart stereochemical control in the synthesis of complex pharmaceutical intermediates and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure materials for advanced R&D and production.

Application

• Chiral Ligand in Asymmetric Catalysis: Used as a precursor or direct ligand for transition metal catalysts in enantioselective hydrogenation, oxidation, and carbon-carbon bond-forming reactions.
• Pharmaceutical Intermediate: A key starting material or resolving agent in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for antiviral and cardiovascular drugs.
• Building Block for Chiral Auxiliaries: Employed in the construction of complex chiral auxiliaries and catalysts used in stereocontrolled organic synthesis.
• Agrochemical Synthesis: Utilized in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Material Science Research: Acts as a monomer or cross-linker in the development of chiral polymers and advanced functional materials.
• Analytical Chemistry: Serves as a chiral selector or stationary phase modifier in chromatography for the separation of enantiomers.

Basic Information

Item	Details
Product Name	(-)-1,4-Di-o-Methyl-L-Threitol
CAS No.	50622-10-1
Molecular Formula	C6H14O4
Molecular Weight	150.17 g/mol
Synonyms	(2R,3R)-1,4-Dimethoxy-2,3-butanediol; (2R,3R)-1,4-Dimethoxybutane-2,3-diol; L-1,4-Dimethoxy-2,3-butanediol; (-)-1,4-Dimethoxy-L-threitol; (2R,3R)-(-)-1,4-Dimethoxy-2,3-butanediol; DMT; L-Threitol 1,4-dimethyl ether
EINECS	Contact for details

Quality Control

Our (-)-1,4-Di-o-Methyl-L-Threitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.