Description

Difluoromethanesulfonamide is a specialized organofluorine building block characterized by its reactive sulfonamide and difluoromethylene groups. This compound matters for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where its unique fluorine chemistry imparts desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoromethylene group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the creation of specialty polymers, coatings, and electrolytes with enhanced chemical resistance and thermal stability.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing sulfonamide group.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and fluorinated compound libraries.
• Chemical Biology Probes: Used to synthesize labeled compounds and probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	Difluoromethanesulfonamide
CAS No.	50585-74-5
Molecular Formula	CH3F2NO2S
Molecular Weight	131.11 g/mol
Synonyms	Difluoromethanesulfonic acid amide; N-(Difluoromethyl)sulfonamide; Sulfonamide, N-(difluoromethyl)-; Methanesulfonamide, N,N-difluoro-; DFMSA; N-Difluoromethylsulfonamide; 1,1-Difluoro-N-sulfonylmethanamine
EINECS	Contact for details

Quality Control

Our Difluoromethanesulfonamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.