Description

2,2-Difluoro-1-(3-(Trifluoromethyl)Phenyl)Ethanone is a high-value fluorinated aromatic ketone building block, essential for introducing the difluoroacetyl and trifluoromethylphenyl motifs into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) with enhanced properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms contribute to improved bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric and optical properties.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty polymers with increased chemical resistance and thermal stability.
• Organic Synthesis Reagent: A versatile electrophile in Friedel-Crafts acylation and nucleophilic addition reactions for introducing fluorinated ketone functionalities.
• Research & Development: A valuable tool compound in academic and industrial labs for exploring new fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	2,2-Difluoro-1-(3-(Trifluoromethyl)Phenyl)Ethanone
CAS No.	50562-07-7
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1-(3-(Trifluoromethyl)phenyl)-2,2-difluoroethanone; 2,2-Difluoro-1-[3-(trifluoromethyl)phenyl]ethanone; 3-Trifluoromethylphenyldifluoroacetyl ketone; α,α-Difluoro-3'-(trifluoromethyl)acetophenone; 2,2-Difluoro-1-(3-trifluoromethylphenyl)ethan-1-one; 1-(α,α-Difluoroacetyl)-3-(trifluoromethyl)benzene; DFTPE
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1-(3-(Trifluoromethyl)Phenyl)Ethanone is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.