Description

Cucurbitacin Iib CAS NO 50298-90-3 is a highly bioactive tetracyclic triterpenoid compound belonging to the cucurbitacin family, known for its potent pharmacological effects. This compound is of significant interest for its role in biochemical research and as a reference standard in analytical applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and natural product sectors for drug discovery, mechanism of action studies, and quality control of botanical extracts.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-cancer and anti-inflammatory therapeutics.
• Biochemical Assays: Used as a potent inhibitor in cell signaling pathway studies, particularly those involving STAT3 and JAK/STAT pathways.
• Natural Product Standardization: Acts as a critical marker compound for the identification, authentication, and quality control of medicinal plant extracts, especially from the Cucurbitaceae family.
• Academic & Contract Research: Employed in university and CRO laboratories for preclinical studies investigating apoptosis, cell cycle arrest, and other cytotoxic mechanisms.
• Cosmeceutical Research: Explored for potential applications in topical formulations targeting inflammation or hyperproliferative skin conditions.
• Veterinary Medicine Development: Investigated for potential applications in animal health products.

Basic Information

Product Name	Cucurbitacin Iib
CAS No.	50298-90-3
Molecular Formula	C₃₂H₄₆O₈
Molecular Weight	558.71 g/mol
Synonyms	Cucurbitacin IIb; Elatericin B; 23,24-Dihydrocucurbitacin F; 23,24-Dihydro-10α-cucurbitacin F; 2β,16α,20(R),25-Tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione; 3β-Hydroxy-23,24-dihydrocucurbitacin F
EINECS	Contact for details

Quality Control

Our Cucurbitacin Iib is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be customized to meet the requirements of GMP, USP, or other pharmacopeial guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.