Description

4-Hydroxy-Tetrahydro-Thiopyran-4-Carboxylic Acid is a versatile sulfur-containing heterocyclic building block with a unique combination of a carboxylic acid and a hydroxyl group on the same carbon atom. This compound is valued for its role as a key chiral intermediate in the synthesis of complex pharmaceutical molecules and advanced materials. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that require specific stereochemistry.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the research and production of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Useful for designing molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, functionalized thiopyran scaffolds.

Basic Information

Product Name	4-Hydroxy-Tetrahydro-Thiopyran-4-Carboxylic Acid
CAS No.	50289-21-9
Molecular Formula	C6H10O3S
Molecular Weight	162.21 g/mol
Synonyms	4-Hydroxytetrahydro-2H-thiopyran-4-carboxylic acid; 4-Carboxy-4-hydroxytetrahydro-2H-thiopyran; Tetrahydro-4-hydroxy-2H-thiopyran-4-carboxylic acid; 4-Hydroxythiane-4-carboxylic acid; 4-Hydroxy-1-thiacyclohexane-4-carboxylic acid; 4-Hydroxy-1-thiane-4-carboxylic acid; 4-Hydroxy-1-thiacyclohexane-4-carboxylic acid; 4-Hydroxy-1-thiacyclohexane-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-Tetrahydro-Thiopyran-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.