Description

3-Phenylisoxazole-5-Boronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of active pharmaceutical ingredients (APIs) and novel organic electronic materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of drug candidates, especially those containing the isoxazole-phenyl pharmacophore for various therapeutic targets.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the isoxazole ring and various aryl/heteroaryl halides, a fundamental reaction in medicinal and process chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand for Catalysis: Can be utilized to develop novel boron-containing ligands for transition metal catalysis.
• Material Science Research: Serves as a monomer or building block for creating organic semiconductors, liquid crystals, and polymers with specific electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	3-Phenylisoxazole-5-Boronic Acid
CAS No.	5868-54-2
Molecular Formula	C9H8BNO3
Molecular Weight	189.98 g/mol
Synonyms	(3-Phenyl-1,2-oxazol-5-yl)boronic acid; 5-(3-Phenylisoxazolyl)boronic acid; 3-Phenyl-5-isoxazoleboronic acid; 3-Phenylisoxazole-5-boronic acid pinacol ester (protected form); 5-Borono-3-phenylisoxazole; 3-Phenyl-1,2-oxazole-5-boronic Acid; B-(3-Phenyl-5-isoxazolyl)boronic acid
EINECS	Contact for details

Quality Control

Our 3-Phenylisoxazole-5-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.