Description

Ophiobolin B is a naturally occurring sesterterpenoid mycotoxin produced by certain fungi, including *Bipolaris* and *Helminthosporium* species. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as a phytotoxin and its ability to induce apoptosis in various cancer cell lines. It serves as a critical reference standard and research chemical for scientists in agrochemical development, phytopathology, and oncology research.

Application

• Phytotoxin Research: Used as a model compound to study plant-pathogen interactions and mechanisms of fungal virulence.
• Anticancer Agent Screening: Employed in biochemical assays to investigate its apoptotic and cytotoxic effects on various cancer cell lines.
• Reference Standard: Serves as a high-purity analytical standard for the identification and quantification of ophiobolins in environmental and biological samples via HPLC or LC-MS.
• Mode of Action Studies: Utilized in research to elucidate the molecular targets and signaling pathways affected by sesterterpenoid toxins.
• Agrochemical Development: Acts as a lead compound or a tool for developing novel plant protection agents or understanding resistance mechanisms.
• Biochemical Reagent: Applied in enzymatic and cell-based assays to study calcium homeostasis and calmodulin antagonism.

Basic Information

Product Name	Ophiobolin B
CAS No.	5601-74-1
Molecular Formula	C25H34O4
Molecular Weight	398.53 g/mol
Synonyms	Ophiobolin B; 3,4-Epoxy-ophiobolin B; 6-Epi-ophiobolin B; Cochliobolin B; Helminthosporium B toxin; (3S,4S,5R,6R,8R,10R,11S,12R,14E)-3,4-Epoxy-14-ethylidene-5,11,12-trihydroxy-6,10-dimethyl-8-propan-2-yl-1-oxacyclopentadec-14-en-2-one
EINECS	Contact for details

Quality Control

Our Ophiobolin B is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and MS for characterization, ensuring the material meets the exacting requirements of advanced life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Keep the container in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.