Description

(R)-2-Hydroxy-α-[(Methylamino)Methyl]-1,3,2-Benzodioxaborole-5-Methanol CAS NO 5579-16-8 is a chiral benzodioxaborole derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a key chiral building block or intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for CNS (Central Nervous System) and anti-infective agents.
• Asymmetric Synthesis: Used as a ligand or catalyst precursor in stereoselective chemical transformations to create enantiomerically pure compounds.
• Boronic Acid/Ester Chemistry: Functions as a protected or functionalized boronic ester precursor for Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes to study enzyme mechanisms or biological pathways.
• Agrochemical Development: Potential intermediate for creating novel, chiral active ingredients for crop protection products.
• Academic Research: Serves as a model compound in methodological studies for new synthetic routes involving boron-containing heterocycles.

Basic Information

Product Name	(R)-2-Hydroxy-α-[(Methylamino)Methyl]-1,3,2-Benzodioxaborole-5-Methanol
CAS No.	5579-16-8
Molecular Formula	C10H14BNO4
Molecular Weight	223.04 g/mol
Synonyms	(R)-2-Hydroxy-α-[(Methylamino)Methyl]-1,3,2-Benzodioxaborole-5-Methanol; (R)-2-Hydroxy-1,3,2-benzodioxaborole-5-methanol, α-[(methylamino)methyl]-; (R)-2-Hydroxy-α-[(Methylamino)Methyl]benzo[d][1,3,2]dioxaborole-5-methanol; (R)-Formoterol Boronic Ester Intermediate; (R)-Formoterol Precursor; (R)-Arformoterol Intermediate; (R)-Bambuterol Boronate Intermediate; (R)-enantiomer of Benzodioxaborole Methanol Derivative
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-α-[(Methylamino)Methyl]-1,3,2-Benzodioxaborole-5-Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request. We adhere to relevant ICH guidelines for the characterization of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.