Description

Benzyl 2-Bromoacetate is a versatile organic ester and alkylating agent, widely utilized as a key synthetic intermediate in fine chemical and pharmaceutical manufacturing. Its primary value lies in its ability to introduce the bromoacetate functional group, enabling the synthesis of complex molecules through esterification and nucleophilic substitution reactions. This compound is essential for researchers and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a high-purity building block for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly those requiring ester or ether linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the bromoacetate moiety is incorporated.
• Peptide Chemistry: Serves as a reagent for the benzyl ester protection of carboxylic acids, which can be later removed under mild hydrogenolytic conditions.
• Material Science: Employed in the modification of polymers and surfaces, introducing reactive sites for further functionalization.
• Organic Synthesis Reagent: Acts as an efficient alkylating agent in C-, O-, and N-alkylation reactions for constructing complex molecular architectures.
• Cross-coupling Reactions: A potential substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, for carbon-carbon bond formation.

Basic Information

Product Name	Benzyl 2-Bromoacetate
CAS No.	5437-45-6
Molecular Formula	C9H9BrO2
Molecular Weight	229.07 g/mol
Synonyms	Benzyl bromoacetate; (Bromomethyl)benzoate; Bromoacetic Acid Benzyl Ester; 2-Bromoacetic Acid Phenylmethyl Ester; Acetic acid, 2-bromo-, phenylmethyl ester; Benzyl α-bromoacetate; Phenylmethyl bromoacetate; NSC 404088
EINECS	226-608-9

Quality Control

Our Benzyl 2-Bromoacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Density	~1.43 g/cm³
Refractive Index	~1.538

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.