Description

2-Acetamido-2-Methylpropanoic Acid is a versatile organic compound featuring both acetamido and carboxylic acid functional groups on a tertiary carbon center. This unique structure makes it a valuable intermediate for synthesizing more complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Mimetics Research: Used to introduce sterically hindered, N-acetylated amino acid analogs into peptide chains to study structure-activity relationships.
• Chiral Auxiliary/Resolving Agent Precursor: Serves as a starting material for creating chiral compounds used in asymmetric synthesis.
• Polymer Modification: Can be incorporated into polymer backbones or used to modify polymer surfaces to alter hydrophilicity or introduce functional handles.
• Bioconjugation Chemistry: The carboxylic acid group allows for coupling to amines, making it useful in linker chemistry for antibody-drug conjugates (ADCs) or diagnostic reagents.
• Agrochemical Synthesis: Employed as an intermediate in the development of certain herbicides and plant growth regulators.

Basic Information

Item	Detail
Product Name	2-Acetamido-2-Methylpropanoic Acid
CAS No.	5362-00-5
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	N-Acetylaminoisobutyric Acid; 2-(Acetylamino)-2-methylpropanoic Acid; 2-Methyl-2-acetamidopropanoic Acid; AIB (Acetamidoisobutyric Acid); α-(Acetylamino)isobutyric Acid; 2-Acetamido-2-methylpropionic Acid; N-Acetyl-α-aminoisobutyric Acid
EINECS	226-340-1

Quality Control

Every batch of 2-Acetamido-2-Methylpropanoic Acid is manufactured under a strict quality management system. We provide comprehensive analytical testing to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing specific results for assay, impurities, and physical properties is supplied with each shipment. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under dry conditions to prevent caking or decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.