Description

1-[(2-Chloroethyl)Thio]-4-Fluorobenzene is a specialized organosulfur and organofluorine compound that serves as a valuable synthetic intermediate in advanced chemical manufacturing. Its bifunctional structure, featuring both a reactive chloroethylthio group and a fluorinated aromatic ring, makes it a critical building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those requiring fluorinated aromatic or thioether motifs for enhanced bioavailability or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, or organic electronic materials that incorporate sulfur and fluorine functionalities.
• Custom Chemical Synthesis: A versatile building block for contract research organizations (CROs) and custom synthesis manufacturers serving diverse R&D needs.

Basic Information

Product Name	1-[(2-Chloroethyl)Thio]-4-Fluorobenzene
CAS No.	5323-03-5
Molecular Formula	C8H8ClFS
Molecular Weight	190.66 g/mol
Synonyms	4-Fluoro-1-[(2-chloroethyl)thio]benzene; 1-Chloro-2-[(4-fluorophenyl)thio]ethane; 2-[(4-Fluorophenyl)thio]ethyl chloride; p-Fluorophenyl 2-chloroethyl sulfide; (2-Chloroethyl)(4-fluorophenyl) sulfide; 4-Fluorophenyl 2-chloroethyl thioether; CAS 5323-03-5
EINECS	Contact for details

Quality Control

Every batch of 1-[(2-Chloroethyl)Thio]-4-Fluorobenzene is produced and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. We provide comprehensive analytical data including HPLC purity, identity confirmation by FT-IR and NMR, and control of key impurities. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.