Description

5-Trimethylsilyl-1-Penten-4-Yn-3-Ol is a specialized organosilicon building block featuring both alkyne and alcohol functional groups, protected by a trimethylsilyl (TMS) moiety. This unique structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and fine chemical production. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring alkyne or protected alcohol functionalities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where its unique carbon skeleton is incorporated.
• Material Science Research: Serves as a precursor for silicon-containing polymers or advanced organic materials with tailored properties.
• Cross-Coupling Reactions: The alkyne group is utilized in Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for the construction of complex natural products and novel organic compounds.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in homogeneous catalysis.

Basic Information

Item	Details
Product Name	5-Trimethylsilyl-1-Penten-4-Yn-3-Ol
CAS No.	5272-35-5
Molecular Formula	C8H14OSi
Molecular Weight	154.28 g/mol
Synonyms	1-Penten-4-yn-3-ol, 5-(trimethylsilyl)-; 5-(Trimethylsilyl)-1-penten-4-yn-3-ol; 3-Butyn-2-ol, 1-(trimethylsilyl)-; 1-(Trimethylsilyl)-3-butyn-2-ol; TMS-Protected Propargylic Alcohol; (3-Hydroxy-1-pentyn-5-yl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 5-Trimethylsilyl-1-Penten-4-Yn-3-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.