Description

(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzene is a specialized cyclic boronic ester derivative, serving as a valuable protected form of phenylboronic acid. This compound is crucial for enabling complex organic synthesis where the boronic acid functionality must be temporarily masked to prevent unwanted side reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in Suzuki-Miyaura cross-coupling and other metal-catalyzed transformations.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing biaryl and heterobiaryl motifs prevalent in active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science & OLEDs: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic displays and devices.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic and research applications.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry and catalysis research.
• Scale-up & Process Chemistry: The cyclic ester's stability makes it suitable for large-scale manufacturing processes requiring robust and consistent boronate reagents.

Basic Information

Product Name	(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzene
CAS No.	5123-13-7
Molecular Formula	C11H15BO2
Molecular Weight	190.05 g/mol
Synonyms	Phenyl-5,5-dimethyl-1,3,2-dioxaborinane; 2-Phenyl-5,5-dimethyl-1,3,2-dioxaborinane; 5,5-Dimethyl-2-phenyl-1,3,2-dioxaborinane; Benzeneboronic acid, cyclic ester with neopentyl glycol; Neopentyl glycol phenylboronate; Phenylboronic acid neopentyl glycol ester; Phenyl B-neopentyl glycol ester
EINECS	Contact for details

Quality Control

Our (5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.