Description

Glycyrrhetinic Acid Methylester, 18-α-(Sg) CAS NO 5092-01-3 is a high-purity, semi-synthetic derivative of glycyrrhetinic acid, a key bioactive triterpenoid from licorice root. This compound is valued for its enhanced bioavailability and potent biological activity compared to its parent acid. It serves as a critical pharmaceutical intermediate and reference standard for research and development in the life sciences.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel anti-inflammatory, antiviral, and hepatoprotective drugs.
• Reference Standard: Used in analytical laboratories for quality control, method validation, and quantification in herbal extracts and finished products.
• Cosmetic & Skincare Actives: Incorporated into formulations for its skin-soothing, anti-irritant, and whitening properties.
• Biochemical Research: A vital tool for studying enzyme inhibition (e.g., 11β-hydroxysteroid dehydrogenase), receptor interactions, and metabolic pathways.
• Nutraceutical Development: Used in the development of high-potency dietary supplements targeting liver health and inflammation.

Basic Information

Product Name	Glycyrrhetinic Acid Methylester, 18-α-(Sg)
CAS No.	5092-01-3
Molecular Formula	C₃₁H₄₈O₄
Molecular Weight	484.71 g/mol
Synonyms	18α-Glycyrrhetinic Acid Methyl Ester; Methyl 18α-Glycyrrhetinate; Enoxolone Methyl Ester (18α); 18α-Olean-12-ene-3β,11β-dihydroxy-30-oic Acid Methyl Ester; (18α)-11β-Hydroxy-3-oxoolean-12-en-30-oic Acid Methyl Ester; 18α-GAM; 18α-Glycyrrhetic Acid Methyl Ester
EINECS	225-809-4

Quality Control

Our Glycyrrhetinic Acid Methylester, 18-α-(Sg) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.