Description

Naphthalene, 2-(Trifluoromethyl)- CAS NO 581-90-8 is a specialized fluorinated aromatic compound, serving as a versatile and valuable building block in advanced chemical synthesis. Its core value lies in the unique properties imparted by the trifluoromethyl group, which enhances lipophilicity, metabolic stability, and electron-withdrawing characteristics in target molecules. This high-purity intermediate is critically needed by R&D and production teams within the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like oncology, CNS disorders, and anti-infectives, where the CF₃ group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the manufacture of modern herbicides, fungicides, and insecticides, where it contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a core or side-chain component in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions to introduce the trifluoromethylated naphthalene moiety.
• Dye & Pigment Intermediate: Used in the production of high-performance, light-fast dyes and pigments.

Basic Information

Product Name	Naphthalene, 2-(Trifluoromethyl)-
CAS No.	581-90-8
Molecular Formula	C₁₁H₇F₃
Molecular Weight	196.17 g/mol
Synonyms	2-(Trifluoromethyl)naphthalene; α,α,α-Trifluoro-2-methylnaphthalene; 2-Methylnaphthalene, trifluoro-; 2-Trifluoromethylnaphthalene; 2-CF3-Naphthalene; 1-(Trifluoromethyl)naphthalene (isomer); NSC 404087; Naphthalene, 2-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our Naphthalene, 2-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by GC-MS, NMR, and IR, to ensure it meets exacting standards for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.