Description

4-(Trifluoromethyl)-Biphenyl is a high-purity fluorinated aromatic compound, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which enhances lipophilicity, metabolic stability, and electronic characteristics in target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a core or side-chain unit in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving charge transport and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Electronic Materials: Serves as a precursor for electron-transport materials and semiconductors in electronic devices.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and structure-activity relationships.

Basic Information

Product Name	4-(Trifluoromethyl)-Biphenyl
CAS No.	581-80-6
Molecular Formula	C13H9F3
Molecular Weight	222.21 g/mol
Synonyms	4-Phenylbenzotrifluoride; 4-Trifluoromethylbiphenyl; 1,1'-Biphenyl, 4-(trifluoromethyl)-; p-(Trifluoromethyl)biphenyl; 4-Trifluoromethyl-1,1'-biphenyl; [1,1'-Biphenyl]-4-yl-trifluoromethane; α,α,α-Trifluoro-4-phenyltoluene
EINECS	209-476-5

Quality Control

Our 4-(Trifluoromethyl)-Biphenyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.