Description

2',4'-Dimethoxy-2,2,2-Trifluoroacetophenone is a specialized trifluoromethylated aromatic ketone, a key building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroacetyl group, which is crucial for introducing the CF3 moiety into target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group for enhanced metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Fluorine Chemistry: An essential reagent for studying nucleophilic addition and substitution reactions on activated trifluoroacetyl aromatics, valuable for methodological development.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2',4'-Dimethoxy-2,2,2-Trifluoroacetophenone
CAS No.	578-16-5
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	1-(2,4-Dimethoxyphenyl)-2,2,2-trifluoroethanone; 2,4-Dimethoxy-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(2,4-dimethoxyphenyl)ethanone; α,α,α-Trifluoro-2,4-dimethoxyacetophenone; 2',4'-Dimethoxy-α,α,α-trifluoroacetophenone; Trifluoro(2,4-dimethoxyphenyl)methanone (tautomeric form)
EINECS	209-427-6

Quality Control

Our 2',4'-Dimethoxy-2,2,2-Trifluoroacetophenone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.