Description

2-Nitroacetophenone is a versatile aromatic ketone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its nitro and carbonyl functional groups make it a valuable building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients and specialty dyes. This high-purity compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality raw materials for their synthesis workflows.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various heterocyclic compounds and active pharmaceutical ingredients (APIs), particularly those containing indole and quinoline structures.
• Agrochemical Synthesis: Used in the manufacturing of certain herbicides and pesticides, where its nitroacetophenone core is incorporated into more complex active molecules.
• Dye and Pigment Manufacturing: Serves as an intermediate in the production of azo dyes and other complex colorants, contributing to the chromophore structure.
• Organic Synthesis Building Block: Employed in research and development for Friedel-Crafts acylation reactions, nitro group reductions, and as a starting material for synthesizing various fine chemicals.
• Chemical Research: Utilized in academic and industrial laboratories for method development and exploring new synthetic pathways due to its reactive functional groups.

Basic Information

Product Name	2-Nitroacetophenone
CAS No.	577-59-3
Molecular Formula	C8H7NO3
Molecular Weight	165.15 g/mol
Synonyms	o-Nitroacetophenone; 1-(2-Nitrophenyl)ethanone; 2'-Nitroacetophenone; Methyl 2-nitrophenyl ketone; 2-Nitrophenyl methyl ketone; ω-Nitroacetophenone; USAF EK-496; NSC 404087
EINECS	209-409-6

Quality Control

Our 2-Nitroacetophenone is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to meet the stringent requirements of our industrial and research clients. A detailed Certificate of Analysis (COA) documenting purity, physical characteristics, and test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	72 - 76 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.