Description

Ethyl 2-(Ethoxymethylene)-4,4,4-Trifluoroacetoacetate is a versatile fluorinated β-ketoester building block, prized for its unique trifluoromethylated and ethoxymethylene functional groups. This compound is essential for the synthesis of complex heterocyclic and fluorinated molecules, offering a critical pathway to introduce fluorine atoms and reactive handles into target structures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated pyrimidines, pyrazoles, and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Synthesis: Used to build fluorinated active ingredients for herbicides, fungicides, and insecticides, leveraging the metabolic stability imparted by the CF3 group.
• Advanced Material Precursor: Serves as a monomer or building block for fluorinated polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in method development and discovery chemistry for creating novel fluorinated compound libraries.
• Coordination Chemistry: Acts as a chelating ligand for metal ions due to its β-ketoester functionality, useful in catalysis and material science.

Basic Information

Product Name	Ethyl 2-(Ethoxymethylene)-4,4,4-Trifluoroacetoacetate
CAS No.	571-55-1
Molecular Formula	C9H11F3O4
Molecular Weight	240.18 g/mol
Synonyms	Ethyl (ethoxymethylene)-4,4,4-trifluoroacetoacetate; 4,4,4-Trifluoro-3-[(ethoxycarbonyl)methylene]-2-butanone; Ethyl 4,4,4-trifluoro-2-(ethoxymethylene)-3-oxobutanoate; Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate; Ethyl (ethoxymethylene)trifluoroacetoacetate; 2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutyric acid ethyl ester; EEMTFA; TFEMA Ester
EINECS	209-340-8

Quality Control

Our Ethyl 2-(Ethoxymethylene)-4,4,4-Trifluoroacetoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.