Description

3,3,3-Trifluoro-2-(Trifluoromethyl)Propionic Acid is a highly fluorinated carboxylic acid derivative, characterized by its unique perfluorinated alkyl chain. This compound is a critical fluorinated building block, prized for its ability to impart exceptional chemical stability, lipophilicity, and metabolic resistance to target molecules. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require sophisticated intermediates for synthesizing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases, where fluorine substitution is crucial for bioavailability and stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Surface Modification: Employed to introduce fluorinated side chains into polymers, granting oil- and water-repellent (omniphobic) properties for coatings, textiles, and specialty plastics.
• Catalyst & Ligand Design: Utilized in organometallic chemistry to create electron-deficient, fluorinated ligands that modify catalyst activity and selectivity in fine chemical synthesis.
• Fluorinated Surfactant Precursor: Acts as a starting material for synthesizing high-performance fluorosurfactants used in fire-fighting foams and industrial cleaners.

Basic Information

Product Name	3,3,3-Trifluoro-2-(Trifluoromethyl)Propionic Acid
CAS No.	564-10-3
Molecular Formula	C4H2F6O2
Molecular Weight	196.05 g/mol
Synonyms	Perfluoroisobutyric Acid; 2-(Trifluoromethyl)-3,3,3-trifluoropropanoic Acid; 3,3,3-Trifluoro-2-(trifluoromethyl)propanoic Acid; PFIBA; Heptafluoroisobutyric Acid; HFIBA; 1,1,1,3,3,3-Hexafluoro-2-(trifluoromethyl)propionic Acid (common misnomer); 2-(Trifluoromethyl)-3,3,3-trifluoropropionic Acid
EINECS	209-264-3

Quality Control

Our 3,3,3-Trifluoro-2-(Trifluoromethyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure it meets exacting specifications for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) with traceable batch data are provided to guarantee consistency, reliability, and compliance with global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and a strong acid; containers must be kept tightly sealed and stored separately from bases and reactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.315 - 1.325
Density (20°C)	1.65 - 1.75 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.