Description

Di-tert-Butyl Malonate is a high-purity diester of malonic acid, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its role as a protected malonate equivalent, offering enhanced stability and selectivity under basic conditions compared to simpler dialkyl malonates. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and complex molecular architectures.

Application

• Pharmaceutical Intermediates: Key starting material and protected synthon in the synthesis of various APIs, including drugs with carboxylic acid or β-keto ester functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require malonate-based molecular frameworks.
• Fine Chemical Production: Acts as a precursor for flavors, fragrances, and other specialty organic compounds.
• Polymer Chemistry: Employed as a monomer or cross-linking agent in the development of specialized polymers and resins.
• Organic Synthesis Reagent: Utilized in classic condensation reactions like Knoevenagel and Michael additions, as well as in decarboxylative alkylation sequences.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for constructing complex carbon chains and heterocyclic systems.

Basic Information

Product Name	Di-tert-Butyl Malonate
CAS No.	541-16-2
Molecular Formula	C11H20O4
Molecular Weight	216.27 g/mol
Synonyms	Di-tert-butyl malonate; Di-tert-butyl propanedioate; Propanedioic acid, bis(1,1-dimethylethyl) ester; Ditert-butyl malonate; Malonic acid di-tert-butyl ester; 2,2-Di-tert-butoxycarbonylethane; DTBM
EINECS	208-777-1

Quality Control

Our Di-tert-Butyl Malonate is manufactured under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography and spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider holding under an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.