Description

Erythromycin B CAS NO 527-75-3 is a 14-membered macrolide antibiotic, a natural congener of the widely used Erythromycin A. This compound is valued for its specific antibacterial activity and serves as a crucial intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of novel antibiotics, microbiological studies, and quality control processes.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel macrolide antibiotic derivatives and prodrugs.
• Microbiological Research: Serves as a reference standard in studies investigating bacterial resistance mechanisms and structure-activity relationships (SAR) of macrolides.
• Quality Control Standard: Employed as a certified reference material (CRM) in HPLC and other analytical methods for assay and impurity profiling of Erythromycin-based products.
• Biochemical Studies: Utilized in enzymatic and receptor-binding assays to explore the mode of action of macrolide antibiotics.
• Veterinary Medicine Development: Investigated for potential applications in animal health products targeting susceptible bacterial infections.

Basic Information

Product Name	Erythromycin B
CAS No.	527-75-3
Molecular Formula	C37H67NO13
Molecular Weight	733.93 g/mol
Synonyms	Erythromycin B; Erythromycin B base; Erythromycin II; (3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione; Antibiotic AB 148; NSC 107412
EINECS	208-408-8

Quality Control

Our Erythromycin B is produced and tested under a strict quality management system. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency, meeting high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.