Description

2-Aminoethoxydiphenyl Borate (2-APB) is a specialized organoboron compound widely recognized as a potent and selective modulator of intracellular calcium signaling pathways. Its primary value lies in its ability to inhibit store-operated calcium entry (SOCE) and inositol 1,4,5-trisphosphate (IP3) receptors, making it a critical pharmacological tool for cell biology and neuroscience research. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences industries studying calcium-dependent cellular processes, receptor function, and potential therapeutic targets.

Application

• Pharmacological Research Tool: A key reagent for investigating the mechanisms of store-operated calcium entry (SOCE) and IP3 receptor-mediated calcium release in various cell types.
• Neuroscience & Cell Biology Studies: Used to study calcium signaling in neurons, glial cells, and other excitable tissues to understand synaptic transmission, neuroprotection, and cell death pathways.
• Drug Discovery & Development: Serves as a reference compound and a starting point for developing novel therapeutics targeting calcium dysregulation in diseases like neurodegeneration, cardiac arrhythmias, and cancer.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify and characterize new modulators of calcium channels and receptors.
• Academic & Institutional Research: A standard research chemical in university and government laboratories for fundamental studies in physiology and pharmacology.

Basic Information

Product Name	2-Aminoethoxydiphenyl Borate
CAS No.	524-95-8
Molecular Formula	C14H16BNO2
Molecular Weight	241.10 g/mol
Synonyms	2-APB; 2-Aminoethyl Diphenylborinate; Diphenylborinic Acid 2-Aminoethyl Ester; (2-Aminoethoxy)diphenylborane; 2-Aminoethoxydiphenylborane; NSC 138747; BRN 2207503; CHEMBL1237024
EINECS	208-376-4

Quality Control

Our 2-Aminoethoxydiphenyl Borate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.