Description

4-Hydroxy-5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is a high-value, functionalized benzaldehyde derivative containing a protected boronic acid pinacol ester group. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophilic partner for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: For the research and production of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: As a building block for creating new herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: In the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: For the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated aldehyde and boronate ester functionality.
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying biological processes and enzyme activity.

Basic Information

Item	Detail
Product Name	4-Hydroxy-5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde
CAS No.	499217-06-0
Molecular Formula	C14H19BO5
Molecular Weight	278.11 g/mol
Synonyms	2-Formyl-4-hydroxy-5-methoxyphenylboronic acid pinacol ester; 5-Methoxysalicylaldehyde-2-boronic acid pinacol ester; 4-Hydroxy-5-methoxy-2-boronobenzaldehyde pinacol ester; (4-Hydroxy-5-methoxy-2-formylphenyl)boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-hydroxy-5-methoxybenzaldehyde; Aldehyde-functionalized arylboronate ester
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.