Description

1,2-Benzenediol,3-[(1S)-2,2,2-Trifluoro-1-Hydroxyethyl]-(9Ci) is a chiral fluorinated catechol derivative, a high-value synthetic intermediate prized for its unique trifluoromethyl and hydroxyl functionalities. This compound is critical for enabling precise stereochemistry and introducing fluorine atoms into target molecules, which can dramatically alter their physical, chemical, and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and synthesis of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the synthesis of specialty polymers and functional materials where fluorine incorporation improves stability and performance.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological mechanisms and diagnostics.

Basic Information

Product Name	1,2-Benzenediol,3-[(1S)-2,2,2-Trifluoro-1-Hydroxyethyl]-(9Ci)
CAS No.	499202-24-3
Molecular Formula	C8H7F3O3
Molecular Weight	208.14 g/mol
Synonyms	(1S)-1-(3,4-Dihydroxyphenyl)-2,2,2-trifluoroethanol; (S)-1-(3,4-Dihydroxyphenyl)-2,2,2-trifluoroethanol; 3-[(1S)-2,2,2-Trifluoro-1-hydroxyethyl]-1,2-benzenediol; (S)-3-(Trifluoromethyl)ethylcatechol; Chiral Trifluoromethyl Catechol Derivative; (S)-TFEC; CAS 499202-24-3
EINECS	Contact for details

Quality Control

Our production of 1,2-Benzenediol,3-[(1S)-2,2,2-Trifluoro-1-Hydroxyethyl]-(9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and potential degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.