Description

3,5-Cyclohexadiene-1,2-Diol, 3-[(1R)-2,2,2-Trifluoro-1-Hydroxyethyl]-, (1S,2R)- (9Ci) is a high-purity, chiral fluorinated diol building block of significant interest in advanced organic synthesis. Its unique stereochemistry and trifluoromethyl group make it a valuable precursor for creating complex molecules with enhanced metabolic stability and bioavailability. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. We supply this material with a focus on consistent quality and reliable purity to support critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and pesticides where the CF3 group can improve activity and environmental profile.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential monomer or cross-linking agent for synthesizing specialty polymers with unique surface properties or optical characteristics.
• Academic & Discovery Chemistry: A valuable tool for methodological studies in fluorination chemistry and stereoselective synthesis.
• Fine Chemical Synthesis: Building block for complex natural product analogs and other high-value specialty chemicals.

Basic Information

Product Name	3,5-Cyclohexadiene-1,2-Diol, 3-[(1R)-2,2,2-Trifluoro-1-Hydroxyethyl]-, (1S,2R)- (9Ci)
CAS No.	499202-15-2
Molecular Formula	C8H9F3O3
Molecular Weight	210.15 g/mol
Synonyms	(1S,2R)-3-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-3,5-cyclohexadiene-1,2-diol; (1S,2R)-3-[(1R)-1-Hydroxy-2,2,2-trifluoroethyl]-1,2-cyclohexanediol; 3-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-3,5-cyclohexadiene-1,2-diol, (1S,2R)-; 1,2-Cyclohexanediol, 3-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-, (1S,2R)-; Fluorinated Chiral Cyclohexadienediol; Trifluoromethyl-substituted Chiral Diol; CAS 499202-15-2
EINECS	Contact for details

Quality Control

Our production of 3,5-Cyclohexadiene-1,2-Diol, 3-[(1R)-2,2,2-Trifluoro-1-Hydroxyethyl]-, (1S,2R)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.