Description

(3S,4S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Hexanone is a high-purity, chiral diazocarbonyl compound featuring a tert-butoxycarbonyl (Boc) protected amine group. This advanced pharmaceutical intermediate is critical for the synthesis of complex bioactive molecules, particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in medicinal chemistry, process R&D, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral, non-racemic compounds for drug discovery and development.
• Medicinal Chemistry Research: Used in the construction of complex molecular scaffolds for biological activity screening and structure-activity relationship (SAR) studies.
• Process Chemistry: Serves as a precursor in the scalable manufacturing of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Peptidomimetics Synthesis: Employed in the preparation of peptide analogs and mimetics due to its protected amino and reactive diazo functionalities.
• Catalyst and Ligand Development: Potential intermediate for creating novel chiral catalysts or ligands used in asymmetric synthesis.
• Academic Research: A valuable reagent for methodologies development in organic synthesis, particularly in reactions involving diazo compounds and chiral induction.

Basic Information

Product Name	(3S,4S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Hexanone
CAS No.	497106-85-1
Molecular Formula	C₁₃H₂₃N₃O₃
Molecular Weight	269.34 g/mol
Synonyms	(3S,4S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-4-methyl-2-hexanone; 1-Diazo-3-[(tert-butoxycarbonyl)amino]-4-methyl-2-hexanone, (3S,4S)-; (3S,4S)-3-(Boc-amino)-1-diazo-4-methyl-2-hexanone; Boc-Diazoketone Chiral Intermediate; (3S,4S)-Boc-AADMH; tert-Butyl (3S,4S)-1-diazo-4-methyl-3-oxo-2-hexan-1-ylcarbamate; Chiral Diazoketone Building Block
EINECS	Contact for details

Quality Control

Our (3S,4S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Hexanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation due to oxidation and moisture. Allow the container to reach room temperature in a desiccator before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.