Description

4-Thiazolecarboxylicacid,4,5-Dihydro-5-Methyl-,Methylester,(4R,5R)-Rel-(9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific three-dimensional architectures, which is critical for developing bioactive compounds. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where precise stereochemistry directly influences the efficacy and safety of final products.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antiviral, antibacterial, or central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the creation of novel, stereoselective pesticides and herbicides where the specific (4R,5R) configuration can enhance target activity and reduce environmental impact.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development and testing of new chiral catalysts and methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Institutional R&D: A valuable tool for universities and research institutes conducting studies in synthetic organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	4-Thiazolecarboxylicacid,4,5-Dihydro-5-Methyl-,Methylester,(4R,5R)-Rel-(9Ci)
CAS No.	496878-20-7
Molecular Formula	C7H11NO2S
Molecular Weight	173.23 g/mol
Synonyms	(4R,5R)-4,5-Dihydro-5-methyl-4-thiazolecarboxylic acid methyl ester; Methyl (4R,5R)-4,5-dihydro-5-methyl-1,3-thiazole-4-carboxylate; rel-(4R,5R)-Methyl 4,5-dihydro-5-methyl-1,3-thiazole-4-carboxylate; (4R,5R)-rel-Methyl 5-methyl-4,5-dihydro-1,3-thiazole-4-carboxylate; 4-Thiazolecarboxylic acid, 4,5-dihydro-5-methyl-, methyl ester, (4R,5R)-rel-; Chiral thiazoline ester; 4-Carbomethoxy-5-methyl-2-thiazoline
EINECS	Contact for details

Quality Control

Every batch of our chiral intermediates is produced and verified under strict quality management protocols. We provide comprehensive analytical data to ensure the chemical purity and enantiomeric/excess (ee) meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (4R,5R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.