Description

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine-boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient, high-yield cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex nitrogen-containing heterocycles. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, as well as by advanced material scientists developing functional organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the boronic ester moiety and aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with complex heterocyclic scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized piperazine-based ligands for metal catalysis.
• Material Science Research: Employed in the construction of organic semiconductors, metal-organic frameworks (MOFs), and other functional polymers.
• Chemical Biology Probe Synthesis: Facilitates the creation of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	496786-98-2
Molecular Formula	C20H32BN3O4
Molecular Weight	389.30 g/mol
Synonyms	2-(6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylate; 1-Boc-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine; 496786-98-2; 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee lot-to-lot consistency and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.