Description

(R)-1-[(R)-2-[2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Phenyl]Ferrocenyl]-Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand crucial for enabling precise stereochemical control in asymmetric catalysis. Its complex, well-defined structure provides exceptional enantioselectivity and catalytic activity, making it a cornerstone for advanced synthetic chemistry. This ligand is primarily sought by research institutions and pharmaceutical manufacturers developing novel active pharmaceutical ingredients (APIs) and fine chemicals where high optical purity is paramount.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Critical for cross-coupling reactions, conjugate additions, and other C-C bond-forming processes requiring high enantiomeric excess (ee).
• Pharmaceutical R&D: Used in the discovery and process development of chiral drugs, including those for oncology, CNS disorders, and cardiovascular diseases.
• Agrochemical Synthesis: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Catalysis Research: Serves as a benchmark ligand for developing new catalytic methodologies and studying structure-activity relationships.
• Fine Chemical Manufacturing: Applied in the synthesis of complex, high-value fragrance ingredients, flavors, and specialty materials.

Basic Information

Product Name	(R)-1-[(R)-2-[2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Phenyl]Ferrocenyl]-Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine
CAS No.	494227-30-4
Molecular Formula	C61H52F12FeO2P2
Molecular Weight	1123.85 g/mol
Synonyms	(R,R)-Bis(3,5-bis(trifluoromethyl)phenyl)[(R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyl]phosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; (R)-1-[(S)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; (R,R)-Josiphos ligand derivative; Chiral Josiphos-type ligand; Ferrocenyl diphosphine ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure identity, purity, and chiral integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (NMR, IR). Our manufacturing aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.