Description

2-(3,5-Difluorophenyl)Malondialdehyde is a specialized organic building block featuring a reactive malondialdehyde unit attached to a difluorinated phenyl ring. This compound matters as a key synthetic intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the difluorophenyl moiety is prized for its ability to modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and target binding.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic frameworks.
• Chemical Biology Probes: Employed in the design of fluorescent tags or molecular probes for studying enzyme activity and cellular processes.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Malondialdehyde
CAS No.	493036-46-7
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	3,5-Difluorobenzylidenemalonaldehyde; 2-(3,5-Difluorophenyl)-1,3-propanedial; Malondialdehyde, 2-(3,5-difluorophenyl)-; (3,5-Difluorophenyl)malondialdehyde; 1,3-Propanedial, 2-(3,5-difluorophenyl)-; 3-(3,5-Difluorophenyl)propanedial
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Malondialdehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.