Description

6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Methylnicotinonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethyl and formyl-substituted aromatic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers seeking to incorporate its distinct molecular framework into new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor for developing new generation pesticides and herbicides with enhanced efficacy.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis and methodological studies.

Basic Information

Product Name	6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Methylnicotinonitrile
CAS No.	492428-96-3
Molecular Formula	C₁₇H₁₄F₂N₂O₂S
Molecular Weight	348.37 g/mol
Synonyms	4-Methyl-6-(difluoromethyl)-2-[[(5-formyl-2-methoxyphenyl)methyl]thio]-3-pyridinecarbonitrile; 2-[[(5-Formyl-2-methoxyphenyl)methyl]thio]-6-(difluoromethyl)-4-methyl-3-pyridinecarbonitrile; Nicotinonitrile, 6-(difluoromethyl)-2-[(5-formyl-2-methoxybenzyl)thio]-4-methyl-; CAS 492428-96-3
EINECS	Contact for details

Quality Control

Our production of 6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Methylnicotinonitrile adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. We support development and commercial projects with material produced under quality guidelines suitable for non-GMP and GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.