Description

[2-[(2-Chloro-6-Methylaminopurin-9-Yl)Methyl]-3-Phosphonopropyl]Phosphonic Acid is a high-purity, synthetic nucleotide analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key building block for the synthesis of novel antiviral and anticancer prodrugs, particularly within the acyclic nucleoside phosphonate class. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleotide-based antiviral and anticancer prodrugs.
• Antiviral Drug Research: Used in the development of novel therapeutic agents targeting DNA viruses and retroviruses.
• Oncology Research: Serves as a key scaffold for creating targeted chemotherapeutic compounds that inhibit cellular proliferation.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the mechanisms of nucleotide-metabolizing enzymes.
• Prodrug Synthesis: Essential for constructing phosphonate prodrugs designed for improved cellular uptake and bioavailability.
• Medicinal Chemistry: A versatile building block for structure-activity relationship (SAR) studies in drug discovery programs.

Basic Information

Product Name	[2-[(2-Chloro-6-Methylaminopurin-9-Yl)Methyl]-3-Phosphonopropyl]Phosphonic Acid
CAS No.	491611-67-7
Molecular Formula	C11H16ClN5O6P2
Molecular Weight	411.68 g/mol
Synonyms	2-Chloro-N-methyl-9-[3-(phosphono)propyl]adenine-3-phosphonic acid; (2-Chloro-6-methylaminopurin-9-yl)methyl-3-phosphonopropylphosphonic acid; 9-[3-(Phosphono)propyl]-2-chloro-N-methyladenine-3-phosphonic acid; Acyclic nucleoside phosphonate analog; cHPMPA derivative; ANP derivative; 491611-67-7; 2-Chloro-6-methylamino-9-(3-phosphonopropyl)purine-3-phosphonic acid
EINECS	Contact for details

Quality Control

Our [2-[(2-Chloro-6-Methylaminopurin-9-Yl)Methyl]-3-Phosphonopropyl]Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.