Description

3-Bromo-5-Chlorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. It is an essential intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, enabling the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex halogenated biphenyl or heterocyclic motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where specific halogenated aromatic systems are required for bioactivity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs), organic semiconductors, and liquid crystals.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and diagnostics.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between aryl halides and aryl boronic acids/esters.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and R&D laboratories developing proprietary compounds.

Basic Information

Product Name	3-Bromo-5-Chlorophenylboronic Acid Pinacol Ester
CAS No.	488850-91-5
Molecular Formula	C12H15BBrClO2
Molecular Weight	316.41 g/mol
Synonyms	(3-Bromo-5-chlorophenyl)boronic acid pinacol ester; 2-(3-Bromo-5-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-chlorobenzeneboronic acid pinacol ester; Pinacol (3-bromo-5-chlorophenyl)boronate; B-(3-Bromo-5-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-chloro phenylboronic acid pinacol ester; Boronic acid, B-(3-bromo-5-chlorophenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chlorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.