Description

Butanedioic Acid, 2-[3-Formyl-4-[(2-Methoxyethoxy)Methoxy]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-, 1,4-Dimethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester and aldehyde functional group. This compound is critical for enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those requiring boronic acid/ester coupling chemistry.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl or vinyl groups, essential for creating diverse chemical libraries and final API structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Process Chemistry Development: Serves as a critical raw material for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Bioconjugation & Probe Synthesis: The reactive aldehyde and protected boronate functionalities allow for its use in creating labeled compounds for biochemical assays and diagnostic tools.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysts.

Basic Information

Product Name	Butanedioic Acid, 2-[3-Formyl-4-[(2-Methoxyethoxy)Methoxy]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-, 1,4-Dimethyl Ester
CAS No.	488713-67-3
Molecular Formula	C23H33BO9
Molecular Weight	464.32 g/mol
Synonyms	Dimethyl 2-(3-formyl-4-((2-methoxyethoxy)methoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)succinate; 2-[3-Formyl-4-[(2-Methoxyethoxy)methoxy]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]butanedioic Acid 1,4-Dimethyl Ester; Succinic acid, 2-[3-formyl-4-[(2-methoxyethoxy)methoxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, dimethyl ester; Boronic ester aldehyde intermediate; Protected boronic acid pinacol ester aldehyde.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for critical synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR (1H and 13C), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep away from heat and incompatible materials. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.