Description

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine is a high-value, heterocyclic organic compound featuring a fused triazolopyrazine core substituted with a trifluoromethyl group. This structure is of significant interest for its potential as a key synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors. The compound, identified by CAS No. 486460-21-3, is supplied under stringent quality control to ensure reliability for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its privileged heterocyclic scaffold.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening against various biological targets.
• Material Science Precursor: Investigated as a precursor for specialty polymers, ligands, or functional materials requiring fluorine-containing heterocycles.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process optimization for client projects.

Basic Information

Product Name	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS No.	486460-21-3
Molecular Formula	C7H9F3N4
Molecular Weight	206.17 g/mol
Synonyms	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine; 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine; 486460-21-3; 3-Trifluoromethyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine; [1,2,4]Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoromethyl)-; TRI-FLUORO METHYL TETRA HYDRO TRIAZOLO PYRZINE
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong alkalis.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.