Description

Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro- (9Ci) is a high-value, fluorinated bicyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique structural framework, which combines the rigidity of a norbornene system with the versatile reactivity of a carboxylic acid and a strategically placed fluorine atom. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in medicinal chemistry for creating novel drug candidates and in material science for specialty polymers.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon for the development of novel active pharmaceutical ingredients (APIs), especially in programs targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides, where the fluorine atom and bicyclic structure can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent for the synthesis of specialty polymers with tailored thermal and mechanical properties, such as fluorinated polyimides or epoxy resins.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chiral ligands or metal-organic frameworks (MOFs) for asymmetric catalysis and separation technologies.
• Fluorine Chemistry Studies: Provides a valuable model substrate for investigating new fluorination methodologies and studying the stereoelectronic effects of fluorine in constrained ring systems.
• Peptidomimetics and Bioisosteres: The carboxylic acid functionality allows for incorporation into peptide chains, where the fluorinated norbornyl unit can act as a rigid, metabolically stable bioisostere for natural amino acids.

Basic Information

Item	Detail
Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro- (9Ci)
CAS No.	484649-24-3
Molecular Formula	C8H9FO2
Molecular Weight	156.15 g/mol
Synonyms	2-Fluoronorborn-5-ene-2-carboxylic Acid; 2-Fluoro-2-norbornene-5-carboxylic Acid; 2-Fluorobicyclo[2.2.1]hept-5-ene-2-carboxylic Acid; 5-Norbornene-2-carboxylic Acid, 2-fluoro-; 2-Fluoro-5-norbornene-2-carboxylic Acid; 2-Fluoro-2-carboxynorborn-5-ene; (1R,4S)-2-Fluorobicyclo[2.2.1]hept-5-ene-2-carboxylic Acid (for specific enantiomer); 2-Fluoro-endo-bicyclo[2.2.1]hept-5-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. For cGMP-grade material or custom purity requirements, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize potential degradation. The container should be stored in a cool, dry, well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.