Description

2-Bromo-1-(2,6-Difluorophenyl)-Propan-1-One is a specialized fluorinated and brominated aromatic ketone building block. This compound is valued for its unique reactivity, serving as a key intermediate in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or possessing specific receptor binding profiles.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluorophenyl and bromo-ketone motifs can impart desirable biological activity and metabolic stability.
• Material Science Chemistry: Serves as a building block for creating advanced organic materials, such as liquid crystals or polymers with specific optical or electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecules.

Basic Information

Item	Details
Product Name	2-Bromo-1-(2,6-Difluorophenyl)-Propan-1-One
CAS No.	481066-21-1
Molecular Formula	C9H7BrF2O
Molecular Weight	249.05 g/mol
Synonyms	2-Bromo-1-(2,6-difluorophenyl)propan-1-one; 2-Bromo-1-(2,6-difluorophenyl)-1-propanone; 1-Propanone, 2-bromo-1-(2,6-difluorophenyl)-; 2,6-Difluorophenyl 2-bromoethyl ketone; α-Bromo-2,6-difluoropropiophenone; 2-Bromo-2',6'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(2,6-Difluorophenyl)-Propan-1-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.