Description

Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its unique halogenated indole core structure makes it an indispensable intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and plant growth regulators due to its bioactive indole scaffold.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and organic electronic materials.
• Academic & Contract Research: Essential for medicinal chemistry programs, structure-activity relationship (SAR) studies, and library synthesis in academic and CRO (Contract Research Organization) settings.
• Chemical Biology: Employed as a probe or labeling agent in biochemical research to study enzyme mechanisms and protein interactions.

Basic Information

Product Name	Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate
CAS No.	480450-89-3
Molecular Formula	C10H7ClFNO2
Molecular Weight	227.62 g/mol
Synonyms	5-Chloro-4-fluoro-1H-indole-2-carboxylic acid methyl ester; Methyl 5-chloro-4-fluoroindole-2-carboxylate; 1H-Indole-2-carboxylic acid, 5-chloro-4-fluoro-, methyl ester; 480450-89-3; 5-Chloro-4-fluoroindole-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.