Description

tert-Butyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbonate is a high-purity, advanced pharmaceutical intermediate and organic synthesis building block. This compound is valued for its role as a protected phenol boronic ester, enabling precise cross-coupling reactions in complex molecule construction. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, crucial in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly where a protected phenolic hydroxyl group is required.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific aromatic frameworks.
• Liquid Crystal & OLED Material Precursor: Employed in the development of advanced organic electronic materials and display technologies.
• Polymer Chemistry: Can be incorporated into polymer backbones or as a functional end-group to modify material properties.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Useful in constructing bifunctional molecules for targeted protein degradation research.

Basic Information

Item	Details
Product Name	tert-Butyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbonate
CAS No.	480438-75-3
Molecular Formula	C17H25BO5
Molecular Weight	320.19 g/mol
Synonyms	4-((tert-Butoxycarbonyl)oxy)phenylboronic acid pinacol ester; BOC-Protected 4-Hydroxyphenylboronic Acid Pinacol Ester; 4-(Boc-Oxy)phenylboronic Acid Pinacol Ester; 4-(tert-Butyloxycarbonyloxy)phenylboronic Acid Pinacol Ester; tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Carbonate; 480438-75-3; 4-(Pinacolatoboryl)phenyl tert-Butyl Carbonate
EINECS	Contact for details

Quality Control

Our tert-Butyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.