Description

tert-Butyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl Carbonate is a high-value, protected boronic ester intermediate crucial for modern synthetic chemistry. This compound matters because it provides a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of active pharmaceutical ingredients (APIs), novel crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing biphenyl or substituted phenyl motifs via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a precursor for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying protein function and interactions.
• Academic & Process R&D: A versatile reagent for method development and scaling up new synthetic routes in organic chemistry laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	tert-Butyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl Carbonate
CAS No.	480438-74-2
Molecular Formula	C₁₇H₂₅BO₅
Molecular Weight	320.19 g/mol
Synonyms	3-((tert-Butoxycarbonyl)oxy)phenylboronic acid pinacol ester; 3-(Boc-oxy)phenylboronic acid pinacol ester; tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate; 3-(Pinacolatoboryl)phenyl tert-butyl carbonate; BOC-Protected 3-Boronophenyl Carbonate Pinacol Ester; 480438-74-2; [3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] tert-butyl carbonate
EINECS	Contact for details

Quality Control

Our tert-Butyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.