Description

n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Formamide is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl bond formations.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors where the boronic acid pinacol ester moiety is utilized for bioconjugation or as a functional handle.
• Academic & Industrial R&D: A fundamental reagent in cross-coupling methodology development and complex molecule synthesis within research laboratories.
• Liquid Crystal & Polymer Chemistry: Intermediate for synthesizing rigid, aromatic cores used in liquid crystal displays and high-performance polymers.

Basic Information

Product Name	n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Formamide
CAS No.	480425-37-4
Molecular Formula	C13H18BNO3
Molecular Weight	247.10 g/mol
Synonyms	3-Formamidophenylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (common misnomer); N-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]formamide; 3-Aminocarbonylphenylboronic acid pinacol ester; m-Formamidophenylboronic acid pinacol ester; B-[3-(Formylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[3-(formylamino)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of n-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Formamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee supply consistency and traceability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.