Description

n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Succinamic Acid is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic acid functionality makes it a stable and effective reagent for palladium-catalyzed carbon-carbon bond formation.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Biology Probes: Can be incorporated into molecules used to study biological processes and protein interactions.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and polymers requiring specific aromatic architectures.

Basic Information

Product Name	n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Succinamic Acid
CAS No.	480424-98-4
Molecular Formula	C16H22BNO5
Molecular Weight	319.16 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenaminium, N-succinyl-; Succinamic acid, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-(N-Succinamido)phenylboronic acid pinacol ester; 4-Succinamidophenylboronic acid pinacol ester; B-[4-(2,5-Dioxo-1-pyrrolidinyl)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Succinamic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent lot-to-lot performance suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability and prevent hydrolysis of the boronate ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.