Description

2-tert-Butoxycarbonyloxyphenylboronic Acid, Pinacol Ester is a sophisticated, protected boronic acid derivative designed for advanced organic synthesis. This compound is crucial for enabling efficient cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity, reliable building blocks for constructing novel molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a key, protected boronic ester reagent for constructing biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs), where the Boc-protected phenol offers orthogonal reactivity.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that incorporate phenolic biaryl motifs.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, ligands for catalysts, and emissive layers in electronic devices.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and inhibitors where the phenol group requires temporary protection during synthesis.
• Scale-up Process Chemistry: Provides a stable and handleable form of the sensitive boronic acid for optimized manufacturing processes.

Basic Information

Product Name	2-tert-Butoxycarbonyloxyphenylboronic Acid, Pinacol Ester
CAS No.	480424-71-3
Molecular Formula	C₁₇H₂₅BO₅
Molecular Weight	320.19 g/mol
Synonyms	2-((tert-Butoxycarbonyl)oxy)phenylboronic acid pinacol ester; (2-((tert-Butoxycarbonyl)oxy)phenyl)boronic acid pinacol ester; 2-Boc-oxyphenylboronic acid pinacol ester; 2-(BocO)C₆H₄Bpin; B-[2-[(1,1-Dimethylethoxy)carbonyl]oxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Hydroxyphenylboronic acid pinacol ester, Boc-protected; 480424-71-3; Boc-protected 2-hydroxyphenyl-Bpin
EINECS	Contact for details

Quality Control

Our 2-tert-Butoxycarbonyloxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to meet the high standards required for synthetic chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.