Description

3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, to construct complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients, as well as for material scientists working on advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating complex aromatic and heteroaromatic scaffolds for kinase inhibitors, CNS agents, and anti-cancer compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific, sterically hindered biaryl motifs.
• Material Science & OLED Development: Serves as a precursor for constructing organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials where precise molecular architecture is critical.
• Ligand & Catalyst Design: Employed in the development of novel bidentate ligands and organometallic catalysts for asymmetric synthesis and other specialized catalytic processes.
• Chemical Biology & Probe Development: Utilized to create molecular probes and tags for studying biological processes, leveraging the boronic ester group for further functionalization.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile
CAS No.	479411-96-6
Molecular Formula	C13H15BBrNO2
Molecular Weight	308.98 g/mol
Synonyms	3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; (3-Bromo-5-cyanophenyl)boronic acid pinacol ester; 3-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl bromide; Boronic acid, B-(3-bromo-5-cyanophenyl)-, pinacol ester; 479411-96-6; 3-Bromo-5-(pinacolboryl)benzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.