Description

2-(3-Chloro-5-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl and heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated phenyl structures.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Diagnostics: Employed in the synthesis of probes, tags, and molecular tools for imaging and diagnostic applications.
• Catalyst & Ligand Development: Utilized in the preparation of novel organometallic catalysts and ligands for asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	2-(3-Chloro-5-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	479411-94-4
Molecular Formula	C12H15BClIO2
Molecular Weight	363.41 g/mol
Synonyms	(3-Chloro-5-iodophenyl)boronic acid pinacol ester; (3-Chloro-5-iodophenyl)pinacolboronate; 2-(3-Chloro-5-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-iodobenzeneboronic acid pinacol ester; Pinacol (3-chloro-5-iodophenyl)boronate; B-(3-Chloro-5-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 479411-94-4
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-5-Iodophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be flushed with inert gas after each opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.