Description

2-(3-Methoxy-5-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a critical intermediate in modern synthetic organic chemistry. Its value lies in enabling efficient, selective carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process R&D teams developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex molecules targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and target engagement.
• Scale-up Process Chemistry: Suitable for use in pilot plant and commercial-scale API manufacturing under GMP guidelines.

Basic Information

Product Name	2-(3-Methoxy-5-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	479411-93-3
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	(3-Methoxy-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(3-Methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methoxy-5-(trifluoromethyl)benzeneboronic acid pinacol ester; Pinacol [3-methoxy-5-(trifluoromethyl)phenyl]boronate; (3-Methoxy-5-trifluoromethylphenyl)boronic acid pinacol ester; 479411-93-3; Boronic acid, B-[3-methoxy-5-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-Methoxy-5-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the rigorous standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.