Description

2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and conjugated systems. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aromatic architectures.
• Material Science: Precursor for organic electronic materials, including monomers for conductive polymers, OLED (Organic Light-Emitting Diode) materials, and liquid crystals.
• Chemical Research & Development: Enables academic and industrial R&D for new synthetic methodologies and the exploration of novel chemical entities via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands and organometallic catalysts.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester
CAS No.	478375-37-0
Molecular Formula	C15H21BO5
Molecular Weight	292.14 g/mol
Synonyms	Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxybenzoic acid methyl ester; Methyl 5-(pinacolatoboryl)-2-methoxybenzoate; 2-Methoxy-5-(pinacolatoboryl)benzoic acid methyl ester; Pinacol 2-Methoxy-5-(methoxycarbonyl)phenylboronate; CAS 478375-37-0
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.