Description

1-(4-Chlorophenyl)-3-[(2,3,4,5,6-Pentafluorophenyl)Sulfanyl]-1-Propanone is a specialized fluorinated and chlorinated organic building block featuring a propanone core with distinct aryl substituents. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts specific electronic and steric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, where the pentafluorophenyl and chlorophenyl groups can contribute to selective biological activity.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic systems.
• Chemical Synthesis Building Block: Employed in organic synthesis for constructing complex molecules via reactions at the ketone or sulfide functional groups, enabling diverse chemical transformations.
• Ligand Precursor: Potential use in the preparation of specialized ligands for catalysis, particularly in transition metal-catalyzed coupling reactions.

Basic Information

Product Name	1-(4-Chlorophenyl)-3-[(2,3,4,5,6-Pentafluorophenyl)Sulfanyl]-1-Propanone
CAS No.	477320-66-4
Molecular Formula	C15H8ClF5OS
Molecular Weight	366.73 g/mol
Synonyms	3-[(Pentafluorophenyl)thio]-1-(4-chlorophenyl)-1-propanone; 1-Propanone, 1-(4-chlorophenyl)-3-[(2,3,4,5,6-pentafluorophenyl)thio]-; 4-Chloro-ω-[(pentafluorophenyl)thio]acetophenone; 1-(4-Chlorophenyl)-3-(pentafluorophenylthio)propan-1-one; Pentafluorophenyl 4-chlorophenacyl sulfide
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorophenyl)-3-[(2,3,4,5,6-Pentafluorophenyl)Sulfanyl]-1-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.