Description

4,6-Methano-1,3,2-Benzodioxaborole-2-Methanamine, Hexahydro-3A,5,5-Trimethyl-α-(2-Methylpropyl)-, (αs,3As,4S,6S,7Ar)- is a specialized, high-purity chiral amine-boronate complex. This compound is a critical advanced intermediate in modern organic synthesis, valued for its unique stereochemistry and functional group compatibility. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Boron Chemistry Research: Serves as a model compound in studying the reactivity and stability of benzodioxaborole heterocycles.
• Agrochemical Development: Potential intermediate for creating novel, targeted pesticides and herbicides with specific chiral activity.
• Material Science Precursor: Investigated for the development of organic electronic materials and boron-containing polymers.
• Academic & Process Chemistry: Used in methodological development and scale-up studies for complex molecule construction.

Basic Information

Product Name	4,6-Methano-1,3,2-Benzodioxaborole-2-Methanamine, Hexahydro-3A,5,5-Trimethyl-α-(2-Methylpropyl)-, (αs,3As,4S,6S,7Ar)-
CAS No.	477254-68-5
Molecular Formula	C16H30BNO2
Molecular Weight	279.23 g/mol
Synonyms	(αS,3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborol-2-methanamine; (1S,2R,4S,5R)-2-Amino-5-isobutyl-3,3,7-trimethyl-6,8-dioxa-3-borabicyclo[3.2.1]octane; Chiral Aminoboronate Ester; Hexahydro-4,6-methano-1,3,2-benzodioxaborole-2-methanamine derivative; CAS 477254-68-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.